Prečo Michael Scofield, mladý, vzdelaný, vysoko inteligentný a finančne zaistený muž, prepadne banku? Prečo pri súdnom pojednávaní pristúpi na všetky podmienky a bez odvolania prijíma päťročný trest vo väzení Fox River? Pretože v tomto vezení čaká na popravu jeho brat Lincoln Burrows. Michael verí v jeho nevinu a tak s dokonale premysleným plánom úteku prichádza, aby ho zachránil. Vo väzení sa však veci nestanú tak, ako si predstavoval a tak musí krom všadeprítomnosti bachárov venovať pozornosť aj zvedavému postoju niektorých spolu-väzňov, ktorí by radi utiekli taktiež.
Through globalization, many countries have been opened and barriers removed to ensure easy trade, travel and cultural diversity. However, this openness has given opportunities to criminals looking to exploit the system and ultimately threaten our global safety. As Europe has become a "safe house" for criminals eluding law enforcers, a special kind of law enforcement team is needed to handle specific ongoing crimes on a global level. "Crossing Lines" is the story of one such team, made up of five international cops, headed by Captain Daniel. The team - comprised of individuals who have little in common - must learn to live and work under the most dangerous and potentially deadly conditions. Housed in an unused storage section underneath the ICC, this mismatched team faces bureaucratic, jurisdictional and cultural obstacles while traversing continents in pursuit of justice.