Lester Burnham lever et behageligt liv i en flot forstad. Men han er havnet i en midtvejskrise. Alting er kedeligt, hans chef er en skiderik og hans kone er ham utro med sin kollega. Lester siger op og begynder at arbejde på en hamburgerrestaurant, dyrker flittigt fitness og tager stoffer. Han bliver også lidt for fascineret af teenagedatterens smukke veninde Angela.

Determined not to turn into her parents, or be drawn into any relationship longer than a one night stand, Zoe constantly struggles with her failing business and love life. Then she falls in love for the first time with Paul. But there's one problem: Paul is married.

A condemned prisoner slowly falls in love with the married female artist who decorates his prison cell. Jin is a convicted killer awaiting execution on Death Row; Yeon is a lonely artist locked in a loveless marriage.