In 1933 New York, an overly ambitious movie producer coerces his cast and hired ship crew to travel to mysterious Skull Island, where they encounter Kong, a giant ape who is immediately smitten with the leading lady.

Primatolog Davis Okoye (Dwayne Johnson), ki sicer ne dovoli, da se mu ljudje čustveno preveč približajo, je navezal neomajno vez z Georgom, izjemno inteligentnim odraslim goriljim samcem, za katerega skrbi že od njegovega rojstva. Toda ko gre po zlu neuradni genetski poskus, se ta nežna opica nenadoma prelevi v gromozansko besnečo zver. In - kar je še huje - kmalu postane jasno, da so podobno preobražene tudi nekatere druge živali. Ti na novo ustvarjeni alfa plenilci sejejo grozo po Severni Ameriki in uničujejo vse, kar se jim znajde na poti. Okoye poišče pomoč genetskega inženirja, ki se je znašel na slabem glasu, da najdeta cepivo, pri tem pa se prebija skozi bojišče, na katerem je vsak hip drugačno stanje; ustaviti mora ne le katastrofo globalnih razsežnosti, temveč tudi rešiti bitje, ki je bil nekoč njegov prijatelj.

After becoming injected with a formula derived from an alien ship, a lab gorilla escapes from his containment and befriends two young boys. The alien formula causes the gorilla to grow to gargantuan size and rampage throughout the city and the boys must find a way to save their simian friend before the army takes him down.

An ivory ape escapes from a freighter and makes its way to Bermuda. Two anthropologists want to save it, but the local authorities hire a big-game hunter to track it down and kill it.