Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, Kusuo Saiki finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss.

Kusuo og de selverklærte vennene hans er tilbake med flere overnaturlige feiltrinn, og problemene fortsetter å tårne seg opp.

Joined by his faithful mecha-butler, Kaz Kaan pursues love, fashion and supernatural forces amid Neo Yokio's sinister high society.