Charting the life of Isabella I of Castile, one of the most important women in Spain’s history, Isabel follows her passionate story from childhood to being crowned Queen. From her political struggles within King Henry IV's court to her wedding to Ferdinand of Aragon, the drama encapsulates the passions, emotions and sacrifices of a woman who refused to just be a figurehead and whose outlook was ahead of her time.

西班牙国王卡洛斯一世即神圣罗马帝国皇帝查理五世，是阿拉贡国王费尔南多二世与卡斯蒂利亚女王伊莎贝拉一世的外孙。彼时他是即将成为欧洲最有权势的年轻人，可这一切充满了危机，对内卡斯蒂利亚贵族的恶意，对外周边国家的战斗。他所追求的荣耀，追求实现的梦想如此艰难，以至于他不得不放弃对家庭生活的渴望。这一切都使他感到孤独。但他还是以顽强意志力和坚韧决心成为了一名成功的国王。