England, 1021. Rob Cole, a boy born in a miserable mining town, swears to become a physician and vanquish disease and death. His harsh path of many years, a quest for knowledge besieged by countless challenges and sacrifices, leads him to the remote Isfahan, in Persia, where he meets Ibn Sina, the greatest healer of his time.

The Inquisition is in full swing in 16th century Flanders. Wanted for his dissident writings, the alchemist doctor Zeno has been wandering Europe under an assumed name for twenty years. But he remains a non-conformist. He returns to his native Bruges, where he thinks he has been forgotten. In this silent labyrinth where the faces of the past resurface, he rediscovers his identity and thus signs his death warrant.