Tytułowa Sakurako Kujou to młoda kobieta z bogatej rodziny, która posiada dziwne hobby - jest zainteresowana kośćmi. Jej wybitne zdolności pozwalają na ich analizowanie, przez co zarówno Sakurako, jak i drugi bohater pierwszoplanowy, Shoutarou Tatewaki, uczeń liceum w mieście Asahikawa, zostają wplątani w wiele tajemniczych spraw.

Born in an affluent family, Sakurako is grown beautiful but rather spirited and speaks roughly. As an osteologist, she reconstructs skeletal remains of animals in her atelier at home when receiving job offers from museums. Deeply inspired by the beauty and majesty of bodies, her eccentricity is remarkable. "Dead bodies speak eloquently." says Sakurako, at the events of examining incidents. She observes bodies and the crime scenes very carefully, and reveals the truth one by one. Kujo Sakurako, the beautiful osteologist, resolves the cases with her expertise hearing the "voice" of bones. How does this extraordinary heroine resolve cases?