When oil is discovered in 1920s Oklahoma under Osage Nation land, the Osage people are murdered one by one—until the FBI steps in to unravel the mystery.

Outlaw Jesse James is rumored to be the 'fastest gun in the West'. An eager recruit into James' notorious gang, Robert Ford eventually grows jealous of the famed outlaw and, when Robert and his brother sense an opportunity to kill James, their murderous action elevates their target to near mythical status.

Doc Holliday travels to Tombstone, Ariz., with prostitute Katie Elder. Although the trip is difficult because Doc is ill with tuberculosis, they eventually reach their destination, where Holliday is reunited with his old friend Marshal Wyatt Earp, who has been clashing with the Clanton gang. Tensions between Earp and the Clantons rise until their infamous final showdown brings it to a head.

Buffalo Bill plans to put on his own Wild West sideshow, and Chief Sitting Bull has agreed to appear in it. However, Sitting Bull has his own hidden agenda, involving the President and General Custer.