An unusual, real-world romance involving relatable people, with one catch - there are three of them! You Me Her infuses the sensibilities of a smart, grounded indie rom-com with a distinctive twist: one of the two parties just happens to be a suburban married couple.

David and Siri are a young couple living in London. During a night out, they meet Camille and a flirtatious game arises where the boundaries are gradually dissolved. In an act of drunken curiosity, they have a threesome.

Neo is a stripper who is running away from the loan shark Thana and his gang, after having an affair with Thana's wife Vanika. One day, the criminals find him in the bar where he works. In attempting to escape, he ends up bumping into two people who will change his life: Shin, a gay boy, the son of Thana, who is frustrated at being rejected by a friend; and Miw, the manager of a gogo bar who is running away from her past. Accidentally, they end up killing one of the gang members who was chasing Neo, which makes them enemies of the gang. Now all three need to find a solution to escape from this situation together, while at the same time managing the physical and sentimental attraction that arises between them.