Chris and his girlfriend Rose go upstate to visit her parents for the weekend. At first, Chris reads the family's overly accommodating behavior as nervous attempts to deal with their daughter's interracial relationship, but as the weekend progresses, a series of increasingly disturbing discoveries lead him to a truth that he never could have imagined.

One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.

Three stories told simultaneously in ninety minutes of real time: a Republican Senator who's a presidential hopeful gives an hour-long interview to a skeptical television reporter, detailing a strategy for victory in Afghanistan; two special forces ambushed on an Afghani ridge await rescue as Taliban forces close in; a poli-sci professor at a California college invites a student to re-engage.