I Mexico betyr Sicario leiemorder. I det lovløse grenseområdet som strekker seg mellom USA og Mexico blir en idealistisk FBI-agent hyret inn av lederen for en elitegruppe til å bistå i den stadig tøffere kampen mot narkotika. Gruppa ledes av en gåtefull konsulent med en tvilsom fortid, og legger ut på en hemmelighetsfull ferd som tvinger Kate til å stille spørsmål ved alt hun tror på for å overleve.
13 August 1961: the GDR closes the sector borders in Berlin. The city is divided overnight. Escape to the West becomes more dangerous every day. But on September 14, 1962, exactly one year, one month and one day after the Wall was built, a group of 29 people from the GDR managed to escape spectacularly through a 135-meter tunnel to the West. For more than 4 months, students from West Berlin, including 2 Italians, dug this tunnel. When the tunnel builders ran out of money after only a few meters of digging, they came up with the idea of marketing the escape tunnel. They sell the film rights to the story exclusively to NBC, an American television station.
Hoppy, California and Johnny come to the ranch of a friend and his daughter, disguised as dude detectives from the east, to investigate the disappearances, without a trace, of several herds of cattle.
An unfit carpenter trails spies through a secret tunnel and blows them up.