Highway Patrol was a syndicated, fictional police action series produced from 1955 to 1959, concerning the activities of the highway patrol and their leader, Dan Matthews (who held no rank). Although filmed in and around the Los Angeles area, the state setting for the stories was never identified, and city and street names were fictionalized.

愛家的好男人亞當·普萊斯在一名陌生人爆出與他妻子有關的驚人內幕之後，拼命尋求解答，卻因此陷入謎團。

督察戴安娜一直安逸於檔案管理的後勤崗位，因緣際會跟元祖級陀槍師姐陳三元、飛虎隊男神蒙漢森合力破案後，被上司韋展超安排加入懸案小組，與一班各有「特色」的警員，在漢森帶領下追查外界不關注的懸案。漢森不滿安娜而互相鬥法，直至揭露安娜因曾被脅持而恐懼用槍，反令二人擦出愛火花！安娜重遇多年前慘遭滅門的補習學生劉達華，他卻加入了黑道……在感情與內疚推動下，安娜能否拿回手槍重新振作，成就新一代的「陀槍師姐」？