After Colony (A.C.) 195. Mankind has moved into space. Thousands of people live on giant orbiting space colonies called "Sides." However, the Earth Government, which rules the colonies, is unjust and cruel. A group of revolutionaries builds five robotic weapons called Gundams and plans to send them to Earth to begin their fight for independence. Piloted by five young men, these Gundams carry the hopes and dreams of freedom of the colonists with them as they descend to Earth to begin Operation Meteor!

Kawakami City is famous for its strong dedication to its samurai ancestors. A healthy fighting spirit is always valued and it's even an important factor for success at school. Yamato, a second year student from Kawakami High school, is always with his close friends (4 boys and 3 girls). They have all known each other since they were young and have done many things together. While they have many other friends, this group of seven is a close-knit, inseparable group. They even have a secret base where they meet. With the new semester, they welcome two girls into their group and shortly after things begin to change...

Dr. Saotome returns from the dead after being seemingly murdered by Getter pilot Nagare Ryoma and threatens the world with his ultimate creation: the Shin Dragon. Ryoma reluctantly teams up with his former co-pilots Jin Hayato and Tomoe Mushashi to combat Dr. Saotome. The pilots must also deal with the mysterious Invaders, aliens that have the ability to possess humans and warp their flesh to form hideous creatures.

In 2017, a group of genius scientists achieve a remarkable breakthrough in bioengineering. However, all the new technologies are put into military use, beginning a new round of arms race. Vanguards, as the most significant achievement of the modern bioengineering and the most advanced weapon, are widely utilized in the race. Although vanguards are exceptionally combat-effective, their life expectancy is shortened by the nanomachines they use. Usually, most vanguards will retire from the army after a number of years in service.

The heroine Liuli has also consumed too much of her lifespan after executing missions for a long time. With only 380 days left in her life, Liuli receives a new mission, to rescue a hostage being held in a civilian facility. It is without doubt a difficult mission for a vanguard like Liuli, who only knows how to kill and battle. However, Liuli obediently decides to accept the mission in the end.

During the mission, Liuli surprisingly finds that the man who holds the hostage was once a vanguard. The former vanguard Zhongrong Zhou cries and asks the government to hand over the son of Eden. As a vanguard, Liuli feels deep contempt against Zhou. To eliminate the scum of the vanguards, a battle between two vanguards begins...