This was the debut for Wile E. Coyote and the Road Runner. It was also their only cartoon made in the 1940s. It set the template for the series, in which Wile E. Coyote (here given the ersatz Latin name Carnivorous Vulgaris) tries to catch Roadrunner (Accelleratii Incredibus) through many traps, plans and products, although in this first cartoon not all of the products are yet made by the Acme Corporation.

The Coyote chases the Road Runner through a maze of mine shafts.

Wile E. Coyote tries to catch the Road Runner using a bear trap with a bird seed bait, a jet rocket, an ice-making machine, and a boomerang.

While cooking a tin can, the Coyote spots a better meal rushing by: the Road Runner.

Wile E. Coyote suspends his chase with the Road Runner to explain to two young boys watching him on TV why he wants to catch the speedy bird.

Wile E. Coyote uses, among other things, a dehydrated boulder to try to catch the Road Runner.

Wile E. Coyote uses a bottle full of bees, a brick wall, a boulder in a catapult, and a harpoon gun in his attempts to catch the Road Runner.

Wile E. Coyote tries to catch the Road Runner using a dynamite stick on a fishing pole, a Christmas present wrapping machine, and ACME Earthquake pills.

Wile E. Coyote tries yet again to catch the Road Runner.

Wile E. Coyote is hungry and schemes to catch the Road Runner.

Wile E. Coyote tries to catch the Road Runner by enclosing himself inside an indestructible steel ball.

Wile E. Coyote's plans for catching the Road Runner involve a giant elastic spring, a gun and trampoline, TNT sticks in a barrel, and tornado seeds.