When the daughter of veteran 911 call center operator Pamela, and her estranged husband Jeremy, a Senior Police Officer, is kidnapped and held hostage, they are left desperate, with no choice but to follow the kidnapper's rules: send messages through dispatch for all police and fire units to scatter to remote locations throughout the city where they are met with chaos. Not knowing who or why, they must race against the clock to make the choice of their lives: save the city — or save their daughter.

Emergency medicine intern Margaux can no longer stand it. During another very hectic and patient-filled shift, she forgets a homeless woman on a stretcher who then dies. Shocked Margaux has no choice but to continue working. But suddenly, her body starts sweating blood uncontrollably.