Following the ascension to power of Taira no Kiyomori, the Minamoto clan is exiled. Minamoto no Yoritomo meets Masako, the sister of Hōjō Yoshitoki and later marries her. Following this marriage, the gears of Yoshitoki's destiny begin to turn.

The 40th NHK Taiga Drama is Hojo Tokimune. It tells the dramatic and turbulent life of young shikken Hojo Tokimune, and his successful defense of Japan from invasion by Mongolia in the 1200's. It is a tragic story of betrayal and clan wars and Hojo Tokimune is at the center of it all. The main focus of the story is Hojo Tokiyori's older sons, their relationship, and their views and actions concerning Kublai Khan's attempted invasion. The two brothers, Tokimune and Tokisuke, are torn apart by politics.

A young orphan named Biwa is taken in by the powerful Taira Clan—also known as the Heike—after their leader witnesses her extraordinary psychic abilities. Unfortunately, what she predicts is a future of bloodshed, violence, and civil war. Inspired by the 12th-century epic tale Heike Monogatari.

The drama centers on Ashikaga Takauji's rise to power, overthrowing the Kamakura shogunate and eventually establishing the Ashikaga shogunate.

The story chronicles the life of Hōjō Masako during the Kamakura Period.