The life of internationally renowned artist and activist Nan Goldin is told through her slideshows, intimate interviews, ground-breaking photography, and rare footage of her personal fight to hold the Sackler family accountable for the overdose crisis.

Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

Americans consume 75% of the world’s prescription drugs. After losing his own brother to the growing epidemic of prescription drug abuse, documentarian Chris Bell sets out to demystify this insidious addiction. Bell’s examination into the motives of big pharma and doctors in this ever-growing market leads him to meet with experts on the nature of addiction, survivors with first-hand accounts of their struggle, and whistleblowers who testify to the dollar-driven aims of pharmaceutical corporations. Ultimately his investigation will point back to where it all began: his own front door.