"Golpe de Suerte" tells the lives of three families from different social classes. First there are the Pérez Flores, who live in Neza and are made up of Ignacio, Julia and their children Ronaldo and Wendy. The second family is made up of Miranda Ortiz and her little son Diego; They live in the Roma neighborhood in the house of César Traven, a generous elderly antiques dealer. And finally there are Brenda Uriarte, her brother Tony, her stepmother Constanza and her stepsister Sabrina, an upper middle class family. Each of these families will experience a radical change in their lives the day they win two hundred million pesos.

Olivia, after having attempted suicide, is investigated for her collaboration in an art smuggling ring with Yaman, her Turkish lover with whom she is in love.