Several generations in the future following Caesar's reign, apes are now the dominant species and live harmoniously while humans have been reduced to living in the shadows. As a new tyrannical ape leader builds his empire, one young ape undertakes a harrowing journey that will cause him to question all that he has known about the past and to make choices that will define a future for apes and humans alike.

Den onde tyran Lord Business vil rive alt, hvad der er LEGO, fra hinanden og lime det sammen igen efter eget forgodtbefindende. Emmet, en helt igennem gennemsnitlig LEGO-figur, bliver ved en fejl udpeget som LEGO-universets redningsmand. Trods sin overvældende mangel på kvalifikationer tager Emmet kampen op og får bl.a. hjælp fra selveste Batman og andre DC-superhelte i deres LEGO-skikkelse.

A tyrannical landlady in Hemet, California lords it over her tenants, pitting them against each other in a web of paranoia spun for deadly results.