By fabricating her biography, Luo Su, a young Chinese white-collar worker from a low-income family, hopes to wed Mr. Win, an alluring bachelor. But when her mother's shocking TV interview exposes her deceit, she loses everything and ends her own life. Left in limbo, she is mystically given one last opportunity to alter her fate within 72 hours - albeit within the body of a man.
For all his life, wealthy businessman Wesley Deeds has done what's expected of him and has settled into a predictable routine. His scripted life begins to change, however, when he meets Lindsey Wakefield, a struggling single mother who works as a night janitor for his corporation and has just been evicted. He offers to help Lindsey get back on her feet and, though he's already engaged, romantic sparks begin to fly. Suddenly, he finds himself torn between what is expected of him and what he really wants.
In New York City, Thom is broke and jobless, illegally working as a taxi driver. Claire is a successful business-woman, but personally she's in shambles - then comes the phone call that her estranged father is in the hospital. Not knowing what to do, Claire hops in Thom's cab and orders him to just drive and so he does. They find themselves in Pennsylvania and Claire makes the rash decision to drive across the country to California. On the road, there are many detours as the obstacles and secrets force them to learn about themselves and each other.
Harold is suffering from a terrifying new disease that is turning him into a zombie. As his condition deteriorates, he and his friendly care worker end up on the run from a group of violent vigilantes.