Arusu believes in magic and it's power to do good in the world. Unfortunately for her, her fellow witches disagree, and use their powers for all sorts of neat tricks, like turning little sprites into their slaves. Realizing that this nightmare is a reality, Arusu sets out to change the ways of the witches, and gets up to some hilarious hijinks along the way.

In the near future, massive hostile beings called "Fiarem" are waging war on Earth. To defend the world from this alien threat, Japan unleashes a special team known as "Ragna Strikers"—six young women wielding advanced weaponry and the ability to grow to gigantic sizes. Ragnastrike Angels follows Ayano Anemori and her friends as they live their daily lives and battle the violent Fiarem.