This was the debut for Wile E. Coyote and the Road Runner. It was also their only cartoon made in the 1940s. It set the template for the series, in which Wile E. Coyote (here given the ersatz Latin name Carnivorous Vulgaris) tries to catch Roadrunner (Accelleratii Incredibus) through many traps, plans and products, although in this first cartoon not all of the products are yet made by the Acme Corporation.

While cooking a tin can, the Coyote spots a better meal rushing by: the Road Runner.

The Coyote chases the Road Runner through a maze of mine shafts.

Wile E. Coyote is hungry and schemes to catch the Road Runner.

Wile E. Coyote uses a bottle full of bees, a brick wall, a boulder in a catapult, and a harpoon gun in his attempts to catch the Road Runner.

Wile E. Coyote uses, among other things, a dehydrated boulder to try to catch the Road Runner.

Wile E. Coyote tries yet again to catch the Road Runner.

A coyote and his rather dim son stalk the sheep that Pluto is guarding.

Father and son coyotes try to sneak into a henhouse that Pluto is guarding.

Wile E. Coyote's plans for catching the Road Runner involve a giant elastic spring, a gun and trampoline, TNT sticks in a barrel, and tornado seeds.

Wile E. Coyote tries to catch the Road Runner using a bear trap with a bird seed bait, a jet rocket, an ice-making machine, and a boomerang.

Wile E. Coyote tries to catch the Road Runner using a dynamite stick on a fishing pole, a Christmas present wrapping machine, and ACME Earthquake pills.

Wile E. Coyote suspends his chase with the Road Runner to explain to two young boys watching him on TV why he wants to catch the speedy bird.

A coyote loses its mate and pups in an attack by wolves. Plagued by human emotions, the coyote attempts to process what it has experienced.

Wile E. Coyote tries to catch the Road Runner by enclosing himself inside an indestructible steel ball.

Aspiring cartoonist and middle-aged gumbuster Cliff Morelli (Jeremy Koerner, Black Cat Whiskey, New York Lately) spends his days at the Santa Cruz Beach Boardwalk performing minimum wage janitorial duties. When he is put on suspension after harassing a teenager and his parents threaten to throw him out of the house, Cliff decides to actively pursue his lifelong animation dreams by reconnecting with his rich brother Jack. After a failed attempt and a string of bad luck, Cliff finds himself at the mercy of the animated characters he has created, and together, they form a devilish plan to exact revenge on all those that have wronged him.