Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.

Marcus Burnett is a henpecked family man. Mike Lowry is a footloose and fancy free ladies' man. Both Miami policemen, they have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.

Two detectives are tasked to investigate the murder of an old man, found bludgeoned to death in a Tokyo rail yard.

Rocky and Dan, war buddies, are prowl car cops on night duty. Dan is a cynic who views all lawbreakers as scum; Rocky feels more lenient. Both are attracted to the radio voice of communicator Kate Mallory; but in person, Kate proves reluctant to get involved with men who just might stop a bullet. By lucky chance, Rocky and Dan cause big trouble for murderous racketeer Ritchie Garris; but when he swears vengeance, Kate's fears may prove justified.