Three Sisters is a daily drama about the lives of two generations of three sisters, portraying their relationships and the difficulties they face.

The queen of the human tribe gave birth to twin girls. Respected by the entire tribe, the older sister Qing Kui, who is gentle and kind, is betrothed to the heavenly prince. The younger sister, Ye Tan, smart and cunning, shunned by her own people, is betrothed to the demon prince. Due to a mix-up, the two sisters are married off to the wrong husbands. It paves the way for two beautiful romances and also ignites a conspiracy that shakes the four realms.

With just one bite, a mysterious homemade cookie turns dreams into reality, but it takes over the elite high school, and deadly consequences await.

Ponwalai, Yodthian's sister, is Prakob's mistress. He devoted his money and himself to her, but she already had another man. When Prakob finds out, he dies of a heart attack and leaves lots of his assets to Ponwalai, which results in his son Noppharuj being furious at both her and Yodthian. Noppharuj chases after them to get revenge, and Yodthian lets him do whatever he wants because she feels guilty over her sister's actions.