Deciding to turn over a new leaf, a group of friends who also happen to be vampires and werewolves move into a house together, only to find that it is haunted by ghosts of people who have been killed under mysterious circumstances. As they deal with the challenges of being supernatural creatures, their desire to be human bonds them.

The anthology horror series follows 25-year-old Atticus Freeman, who joins up with his friend Letitia and his Uncle George to embark on a road trip across 1950s Jim Crow America to find his missing father. They must survive and overcome both the racist terrors of white America and the malevolent spirits that could be ripped from a Lovecraft paperback.