Reklamemanden Roger Thornhill mødes med et par kolleger på Plaza Hotel i New York til et par drinks. Her forveksles han med en George Kaplan og bortføres. Det lykkes dog Thornhill at flygte, men ingen tror på hans historie, og snart er han også eftersøgt for mord.

Committed pacifist Tom Jordan's decision to help former President Rivera escape a military coup is a simple act of mercy that takes him and his wife to the edge of despair. It turns them into outlaws and fugitives, hunted by a vicious South American regime; yet it could also bring them together in a way they have never been before.