New Orleans judge Michael Desiato is forced to confront his own deepest convictions when his son is involved in a hit and run that embroils an organized crime family.

A host of demigods have inherited the world after the Demon King has died, and a battle to determine the mightiest ensues.

The anime's setting is a fictional Japanese city named Sugomori City. One day, Noriko Sonosaki tells her classmate Katsuhira Agata, "You have been selected to be a Kiznaiver." The Kizuna System, which allows Katsuhira to share his wounds, connects him to the classmates whose lives and personalities completely differ from his. The Kizuna System is an incomplete system for the implementation of world peace that connects people through wounds. All those who are connected to this system are called Kiznaivers. When one Kiznaiver is wounded, the system divides and transmits the wound among the other Kiznaivers. Sugomori City is built on reclaimed land, but as the years go by, the city's population is decreasing. The story is set in this town where Katsuhira and the others live.

Ferhat is a hitman working for his criminal uncle. Aslı is a young and idealistic doctor. One day, their roads crossed in the most unexpected way: Aslı is forced to operate on a man that Ferhat had shot.