La sèrie descriu les aventures d'un viatger del temps alienígena conegut com «el doctor», que viatja amb una nau espacial i temporal, la TARDIS, que per fora s'assembla una cabina de policia. Els senyors del temps poden regenerar-se el cos quan s'apropen de la mort, la qual cosa fa que en canviï l'aspecte. Amb els seus companys, explora el temps i l'espai, resol problemes i arregla injustícies.
Puberty Syndrome—a rumored, mysterious syndrome that only affects those in their puberty. For example, a bunny girl suddenly appeared in front of Sakuta Azusagawa. The bunny girl's real identity is Mai Sakurajima, a teenage celebrity who is currently an inactive high school senior. For some reason, her charming figure does not reflect in the eyes of others. In the course of revealing the mystery behind this phenomenon, Sakuta begins to explore his feelings towards Mai. Set in a city where the skies and seas shine, Sakuta unfolds the meaning behind his bizarre encounters on women with the said syndrome.
After a nervous breakdown derailed Jocelyn's last tour, she’s determined to claim her rightful status as the greatest and sexiest pop star in America. Her passions are reignited by Tedros, a nightclub impresario with a sordid past. Will her romantic awakening take her to glorious new heights or the deepest and darkest depths of her soul?