В сериала се разказва за едно 10- момче със сили да се превръща в 10 и повече различни извънземни. Разказва се също и за братовчедка му Гуен и дядо им Макс. Когато пораства, Бен е най-добрият "плъмър" - нещо като полицай срещу извънземни. Тогава той е национален супергерой и притежава 10 000 извънземни!

A year after the events that took place during the "Final Battle" and equipped with an all-new completed Omnitrix, 16-year-old Ben Tennyson has to face new enemies.

With the fifth offshoot of the "Ben 10" franchise, the animated series returns to its roots and its original name, bringing 10-year-old Benjamin "Ben" Tennyson, his cousin Gwen, and Grandpa Max back to life on a new summer vacation journey. As in the original, the stories in the remake of the series also spin around an alien wristwatch called "the Omnitrix," with the help of Ben can turn into ten different aliens, which come up with different supernatural powers. He fights enemy aliens and experiences with his grandfather and cousin the most exciting vacation imaginable.

With his secret identity now revealed to the world, Ben Tennyson continues to fight evil as a superhero with the help of the newly acquired Ultimatrix.

Five years later, 15-year-old Ben Tennyson chooses to once again put on the Omnitrix and discovers that it has recalibrated and can now transform him into 10 brand new aliens. Joined by his super-powered cousin Gwen Tennyson and his equally powerful former enemy Kevin Levin, Ben is on a mission to find his missing Grandpa Max. In order to save his Grandpa, Ben must defeat the evil DNAliens, a powerful alien race intent on destroying the galaxy, starting with planet Earth.