Akira Fudo learns from his best friend Ryo Asuka that demons will revive and reclaim the world from humans. With humans hopeless against this threat, Ryo suggests combining with a demon. With this, Akira becomes Devilman, a being with the power of demon but with a human heart.
Koshiro and Nanoka fall deeply in love, then discover they are the children of their divorced estranged parents... making them brother and sister. How will their relationship turn out?
Fem elever på den største offentlige high school i Brooklyn kaster sig ud i et kaotisk liv, hvor de kæmper for succes, overlevelse, frigørelse og for at erobre fremtiden.