Akira Fudo learns from his best friend Ryo Asuka that demons will revive and reclaim the world from humans. With humans hopeless against this threat, Ryo suggests combining with a demon. With this, Akira becomes Devilman, a being with the power of demon but with a human heart.

Koshiro and Nanoka fall deeply in love, then discover they are the children of their divorced estranged parents... making them brother and sister. How will their relationship turn out?

Five students at the largest public high school in Brooklyn take on a chaotic world as they fight to succeed, survive, break free and seize the future.