Ripley, the sole survivor of the Nostromo's deadly encounter with the monstrous Alien, returns to Earth after drifting through space in hypersleep for 57 years. Although her story is initially met with skepticism, she agrees to accompany a team of Colonial Marines back to LV-426.

On a deep space mining mission to a remote planet, an ancient religious relic - thought to be proof of the existence of God - is unearthed and brought aboard. When the unholy artifact unleashes a long-dormant alien race, its glimpse of Heaven transforms the ship into a living Hell. A prequel to the events of the 2008 video game Dead Space.