A pampered Beverly Hills chihuahua named Chloe who, while on vacation in Mexico with her owner Viv's niece, Rachel, gets lost and must rely on her friends to help her get back home before she is caught by a dognapper who wants to ransom her.

Notorious Baltimore criminal and underground figure Divine goes up against Connie & Raymond Marble, a sleazy married couple who make a passionate attempt to humiliate her and seize her tabloid-given title as "The Filthiest Person Alive".