Serialul se învârte asupra trei fetițe, Blossom, Bubbles și Buttercup, cunoscute ca fetițele Powerpuff, care dețin din naștere superputeri. Au fost create prin combinarea ingredientelor zahăr, condimente și tot ce-i drăguț (sugar, spice and everything nice în engleză) la care s-a adăugat accidental elementul X (engl.: Chemical X). Ele își dedică viața luptei împotriva criminalității și a răului din lume în orașul Townsville, alături de creatorul și totodată tatăl lor adoptiv, Profesorul Utonium.
By force of circumstances, a 30-year-old single man with a full-time job suddenly starts raising a 6-year-old girl. While running each other ragged, the two of them gradually grow into a "family".
Anzu, Hiiragi, and Koume are three girls who attend the lively Hanamaru Kindergarten. There they have lots of adventures with their classmates and with Naozomi Tsuchida, their teacher who has just started working fresh out of school.
Lovable pug Chip starts kindergarten, makes new friends and tries new things -- with a little help from Potato, her secret mouse pal.
The show is a spin off from the Shaun the Sheep animation which itself is a spin off from the Aardman series Wallace & Gromit, which introduced the character of Shaun.
Shinichiro Hanasaki, a former detective with the police department, is currently engaged in running a nursery called “Smiling Garden.” He wishes to help poorer families and single parents by offering very low fees for childcare, but this leaves the nursery struggling financially. To replenish the budget, Shinichiro decides to open a private detective agency at night.