在1996年時人類被致命病毒侵襲，直到2035年地球上只有在地底存活下來少數的人類。科學家們為了追查當年病毒擴散的原因，讓囚犯占士·科爾（James Cole，布斯·韋利士飾演）作為志願者透過時間旅行回到1996年去調查，線索是該年一則提及「12猴子軍團」的電話留言錄音，並設法阻止事件的發生。 第一次傳送出現錯誤，科爾被送到1990年的巴爾的摩。因為他向人們描述6年後將有50億人口死於一場病毒災難，而被精神病醫生嘉芙蓮·雷莉診斷為精神思·裂和妄想症，並送入了精神病院。幸好科學家們將他傳送回了2035年。隨後，科學家們又一次將他傳送回1996年，科爾發現病毒的發源地是在費城。他挾持了嘉芙蓮開車送他到費城，並找到了12猴子軍團。起初，嘉芙蓮不相信他的話，但是隨着一些事件的發生，她逐漸相信並愛上科爾，並決心幫助他挽救人類的命運。 他們發現12猴子軍團原來是個動物解放運動協會，它的組織者是六年前科爾在精神病院的病友謝菲（Jefferey Goines，畢·彼特飾演），謝菲之父為著名的病毒專家科蘭德。科爾一度以為是自己當年在精神病院中關於病毒襲擊的談話啟發了謝菲毀滅世界的靈感，嘉芙蓮也偶然間留下一段電話留言警告12猴子軍團的可能威脅（這就是前述被未來科學家反覆研究的線索）。 然而，後來謝菲及其12猴子軍團成員的大行動其實只是將科蘭德捆送動物園囚禁以抗議其動物活體實驗，並釋放關在動物園的動物任牠們在費城四處遊蕩。當科爾發現那場致命的病毒根本與12猴子軍團無關後，他和嘉芙蓮決定不再理會，並打算飛離費城享受平淡美好的生活。在機場兩人卻發現科蘭德博士的助手彼得斯才是世界末日的罪魁禍首，當時他正準備運送病毒到最早爆發疫情的幾個城市。但是正當科爾準備開槍阻止彼得斯時，他卻被趕到的警察當場擊斃，而彼得斯則已開始了散佈病毒的行動。在科爾臨死時，幼年的科爾正好經過此處，老科爾才發現自己被殺的這一幕原來就是自己經常在夢中夢到的場景。
阿哥占美（卓寧泰坦 飾）係失業嘅廢中，細佬佳德（阿當載華 飾）係受盡白眼嘅獨臂酒保；呢對出名黑仔嘅盧根兄弟唔想日子愈過愈霉，精心策劃一場大反擊，企圖潛入世界級賽車場地底金庫，偷偷運走所有現金﹗兩人開始招兵買馬，仲悉心安排爆破專家早爆（丹尼爾基克 飾）逃獄幫拖。一切準備就緒，但盧根家嘅惡運又開始令諸事不順，更引來FBI姬遜（希拉莉絲韻 飾）如狼似虎嘅目光…
一位傑出的科學家－蘇珊泰勒博士和她的丈夫－彼德曼恩博士，兩人聯手成功地杜絕了紐約市某種威脅許多孩童性命的傳染病。蘇珊重組了不同物種的DNA（染色體），創造出一種對抗該疾病病原的生物抗原體，她將此新物種命名為〝猶大種〞，並藉由彼德的幫助，將這個生物抗原體引進紐約市的生態系統中。三年之後，此種看似遺傳學界天才的神奇物種展開了其報復行動。他們創造了抗原自行發展成生命體，因為他們改變了大自然的生態平衡，於是大自然開始反擊...
An earthquake releases a strain of mutant cockroaches with the ability to start fires, which proceed to cause destructive chaos in a small town. The studies carried out by scientist James Parmiter, however, reveal an intent with much more far-reaching consequences.
Five tales in the style of classic '50s horror comics, involving a murdered man emerging from the grave, a meteor's ooze that makes everything grow, a snack for a crated creature, a scheming husband, and a malevolent millionaire with an insect phobia.
A nice guy has just moved to New York and discovers that he must share his run-down apartment with a couple thousand singing, dancing cockroaches.
Manga artist Gengo Odaka lands a job with the World Children's Land amusement park only to become suspicious of the organization when a garbled message is discovered on tapes. As Gengo and his team investigate, Godzilla and Anguirus quickly decipher the message and begin their own plan of action.
一場紛爭過後，有位紐奧良酒保將遺落在現場的手機撿了起來，卻開始收到詭異不祥的簡訊，他的理智也逐漸崩潰。
Detective Klaski investigates the death and mutilation of three men and soon crosses paths with Remy, an entomologist. Soon, he discovers that she is being stalked by a giant shape-shifting insect who is bent on taking over New York.
Horrifying shocker as a biological experiment goes haywire when meat-eating mutant roaches invade an island community, terrorizing a peaceful New England fishing village and hideously butchering its citizens.
Following World War III, four survivors at an desert military installation attempt to drive across the desolate wasteland of America to Albany, where they hope more survivors are living, using a specially built vehicles to protect themselves against the freakish weather, mutated plant and animal life, and other dangers encountered along the way.
The cockroaches of Saito's apartment live in peace with their human host, who gives them lots of space to breed and plenty of leftovers to munch on. In the midst of these high living times, Naomi and Ichiro plan to get married and start a family. But when a hard-bitten stranger roach named Hans appears with news of war with the humans across the lawn, it foretells disruption-not only of Naomi and Ichiro's relationship, but of the hive's entire way of life.
Leaving their hometown of Fulchester in the North of England, Sandra and Tracey head for the bright lights of London, shagging and boozing their way to fame and fortune.
After the mayor uses a potentially dangerous substance to protect the local plantation, the lakeside town of Mountview, in California, is attacked by a lethal species of large cockroach. After some of the town's inhabitants are killed, the mayor enlists the help of eccentric pest exterminator General George S. Merlin in order to prevent further harm to the local dwellers.
A reporter investigating the bizarre death of a woman who leaped from a building in flames finds herself mixed up in a cult of witches who are making her part of their sacrificial ceremony during the Christmas season.
Bianca an emotionally unstable office worker is asked by a mysterious client to deliver documents insisting she must deliver them herself in person. On her arrival Bianca is kidnapped. Her captor, leader of a cult, drugs Bianca whilst tormenting her with continuous relentless indoctrination, forcing Bianca her to question the veracity of her memories, even those most life forming, as a victim of child abuse.
A cockroach's infestation triggers a rift in the relationship between Ingrid and her fiancé. Haunted by terrifying hallucinations, Ingrid spirals into doubt and finds it difficult to distinguish what is real and what is not.
A young pilot narrowly escapes the destruction of her home in a stolen ship, only to be followed by the colossal cockroach responsible.
First of a Trilogy: In a New York ravaged with acid rains, a man in his twenties meets a mysterious, yet familiar young woman who disrupts the banality of his day-to-day existence. Together, they will embark on a surreal journey with a devastating climax.