Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'.

At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.

After accidentally breaking a statue of the guardian god of the Asakusa district, middle school students Kazuki, Toi and Enta are transformed into kappas -creatures from japanese folklore- by Keppi, self-proclaimed prince of the Kappa Kingdom. If they want to regain their human form, they must collect the five Dishes of Hope for him, which fulfill the wishes of whoever possesses them. To do so, they will fight against the kappa-zombies and extract their "shirikodama", the mythical organ containing humans' deepest desires. Two policemen, Reo and Mabu, are the ones behind this evil scheme, turning humans into zombies as agents of the Otter Empire, enemy of the Kappa Kingdom since ancient times. In the guise of "Kappazon, Inc.", they control society by manipulating the desires of the masses for their own goals. To succeed in their mission, the boys must be connected through the "Sarazanmai", revealing their most intimate secrets in the process...

Child of divorced parents, Louis 12 years old, has two of everything - two homes, two sets of parents, two step siblings, two rooms and soon two personalities, because life feels pretty schizophrenic.