Cinco amigas inician un viaje a una isla caribeña para celebrar la despedida de soltera de una de ellas, Carina. Al final, otra amiga, Danielle, decide ir, pero llega un día mas tarde. Para su sorpresa, sus amigas no regresarán de una excursión a una isla abandonada conocida como Isla Mujeres.

Regan, Nicole, Lynette et Isabel débarquent aux Caraïbes où elles s'apprêtent à fêter l'enterrement de vie de jeune fille de leur amie Carina. Elles décident de partir en excursion sur une île déserte. Mais au moment de regagner leur hôtel, aucune navette ne se présente pour les récupérer.

Bride-to-be Carina (Durance) decides to take four friends to an exotic Caribbean island for a hen party to remember. After arriving at the luxurious resort the women take a boat ride to an isolated island where they can bask in the sun and sand - and it's there that the nightmare begins. The captain of the boat forgets to pick the girls up, leaving them stranded and forcing them to use a deserted house as a makeshift shelter. Then, one by one, the girls start to vanish. With Carina's big day the last thing on the girls minds they start to wonder whether they will see out the night...

Um grupo de amigas decide fazer a despedida de solteiro de uma delas em uma ilha do Caribe. As moças fazem um passeio de barco, mas o capitão as esquece no local e elas vão desaparecendo misteriosamente.