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Mark O'Keefe is a comedy screenwriter for feature films and television. He wrote and produced the 2003 film Bruce Almighty, starring Jim Carrey and the 2006 film Click, starring Adam Sandler. O'Keefe resides in Los Angeles.

His brothers are Broadway and movie songwriter Laurence O'Keefe (also called Larry), composer and lyricist of shows like Bat Boy: The Musical and Legally Blonde: The Musical; and Seinfeld writer and producer Daniel O'Keefe (also called Danny). Their father, Daniel O'Keefe, Sr., invented their private family holiday Festivus, which gained national exposure when depicted in an episode of Seinfeld (written by Danny), and which is now celebrated across the globe.

Mark created the short-lived TV show The O'Keefes, which was loosely based on his family (except that Larry was turned into a girl, named Lauren). The show, starring Judge Reinhold, was on The WB in the summer of 2003, but only 5 episodes aired before it was cancelled. The show generated controversy among people who felt that it depicted homeschooling in a negative light.

His most recent project, Evan Almighty was released in the Summer of 2007.

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