Carmen Cuba's career began in 1999 with filmmaker Larry Clark (Bully and Ken Park) which led to a long-standing collaboration with Oscar-winning director Steven Soderbergh casting everything from his experimental film Bubble to last year's Magic Mike's Last Dance. Additionally, her work with Ridley Scott includes The Martian, Alien Covenant, All the Money in the World. Cuba's recent film highlights include: Leos Carax's Annette, The Matrix Resurrection by Lana Wachowski, The Power of the Dog by Jane Campion and NOPE by Jordan Peele. In 2022 she worked on Pedro Almodovar's first English-language film, Madonna's autobiographical epic, as well as Zoe Kravitz and Finn Wolfhard's feature directorial debuts, and Haunted Mansion for Justin Simien.

In television she has worked with filmmakers Soderbergh (Behind the Candelabra, The Knick), Luca Guadagnino (We Are Who We Are), Alex Garland (Devs), Patty Jenkins (I Am The Night), and on highly acclaimed series by Tarrell McCraney (David Makes Man), Tanya Saracho (Vida), Amy Seimetz (The Girlfriend Experience), Lena Waithe (The Chi) and Andrew Haigh (Looking) as well as on all four seasons of Stranger Things with the Duffer Brothers. 2023 highlights are Swarm for Donald Glover and Janine Nabers, and another Glover series Mr. and Mrs Smith, as well as Soderbergh's upcoming limited series Full Circle, the Star Wars series The Acolyte for Leslye Headland, and the Marvel limited series Wonder Man for Destin Cretton all in post.

Among other awards and nominations, she's been nominated for five Emmys for Outstanding Casting, winning one for Behind the Candelabra and another for Stranger Things.