Arlene Francis (born Arline Francis Kazanjian) was an American actress, radio talk show host, and game show panelist. She is known for her long-standing role as a panelist on the television game show What's My Line?, on which she regularly appeared for 25 years, from 1950 through the mid-1970s.

Arlene Francis (Boston, Massachusetts, 20 d'octubre de 1907 - San Francisco, Califòrnia, 31 de maig de 2001) va ser una actriu nord-americana d'origen armeni, presentadora de programes de ràdio i televisió i panelista de programes de jocs.