Beth grew up in Douglassville, PA, crafting short films with her brother, director Jim Mickle, before moving to New York to attend Columbia University. While in college, she continued working on her brother’s NYU short films, ultimately leading to her career as a production designer for film and television. One of her earliest collaborations was with directing duo Ryan Fleck and Anna Boden on “Half Nelson,"  which earned a Best Actor Academy Award nomination for Ryan Gosling.

In 2009, she teamed with auteur director Nicolas Winding Refn on "Drive,"  for which she received an Art Directors Guild nomination for Excellence in Production Design. She worked with Refn again in Bangkok on “Only God Forgives,"  which debuted at the Cannes Film Festival in 2013. 

She partnered with Ryan Gosling on his directorial debut, “Lost River,"  which premiered at Cannes in 2014. Other credits include "Focus,"  “2 Guns,"  and "Arbitrage,"  as well as season one of HBO’s “The Deuce,"  created by David Simon and George Pelecanos. Her other honours include being nominated for a BAFTA award for her work in “An Englishman in New ork," b being recognised by Glamour magazine as one of the “Under 35” women in film to watch, and landing on the Below-the-Line Impact Report for Variety in 2013. She enjoys working abroad and has experience working on locations in Argentina, Russia, Thailand, the Dominican Republic, and throughout Europe. 

Beth currently lives in Hudson, NY, with her partner, production designer Russell Barnes, and to this day, she and her brother continue their creative film collaborations. 

She has collaborated with writer-director and DC Studios co-president James Gunn many times, with her now working on Superman (2025).

She is represented by Jasan Pagni at WME.