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Wilson Mizner (May 19, 1876 – April 3, 1933) was an American playwright, raconteur, and entrepreneur. His best-known plays are The Deep Purple, produced in 1910, and The Greyhound, produced in 1912. He was manager and co-owner of The Brown Derby restaurant in Los Angeles, California, and was part of the failed project of his older brother, Addison, to create a new resort in Boca Raton, Florida. Taking considerable liberties with their lives, he and Addison are the protagonists of Stephen Sondheim's musical Road Show (alternately known as Wise Guys, Gold!, and Bounce).

Wilson's playwriting career was undermined by his laziness and an opium addiction that started when he was prescribed painkillers after an assault. He was convicted in 1919 for running a gambling den on Long Island, and received a suspended sentence. After he was nearly beaten to death — the details are unknown — at Addison's invitation he followed him to Palm Beach, Florida, where Addison and other investors were announcing a new resort, Boca Raton, Florida. Wilson was secretary and treasurer of the Mizner Development Corporation created in 1925, in effect working for his brother. Unfortunately Addison's plans were financially unsound and the Corporation was forced into receivership within a year, and bankruptcy soon after.

When Wilson returned to California he obtained backing from Jack L. Warner and Gloria Swanson and bought into and managed the Brown Derby, and wrote screenplays for some of the early talkies. His best known film work is the screenplay for the Michael Curtiz film 20,000 Years in Sing Sing. Wilson called his Hollywood years "a trip through a sewer in a glass-bottomed boat." Several of the brothers' friends from New York, including Marie Dressler and Ben Hecht, helped him in his later escapades.