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Virginia Sale (May 20, 1899 – August 23, 1992) was an American character actress whose career spanned six decades, during most of which she played older women, even when she was in her twenties. Over the 46 years she was active as an actress, she worked in films, stage, radio and television. She was famous for her one-woman stage show, Americana Sketches, which she did for more than 1,000 performances during a 15-year span.

Married to actor and studio executive Sam Wren, she co-starred with him in one of the first television family comedies, Wren's Nest, in the late 1940s and early 1950s. She gave birth to fraternal twins, Virginia and Christopher, in 1936. Later in her career she worked on television, and in commercials. She died from heart failure at the age of 93 at the Motion Picture and Television Hospital in 1992.