When a defeated Kian finds himself in a dark place, will Jac be able to pull him back from the edge? Meanwhile, a past acquaintance puts Max in a compromising position.

Jac and Kian return to work, but can they support each other and conquer their demons? Demoted and back in the trenches, Serena must find a role for herself. And will Sacha’s efforts to help with Essie’s home life only push her into Ben’s arms for good?

With Jason's job in jeopardy, can Serena afford to put her neck on the line for her nephew? Tracey McKendrick brings trouble to Holby. How far will Nicky go to protect her mum? And can Essie trust boyfriend Ben enough to share the secret of baby Isla’s illegal adoption?

On Holocaust Memorial Day, Sacha's beloved great-aunt - a Holocaust survivor - is admitted in very poor health. Meanwhile, Cameron sees red while dealing with a stabbing victim.

It’s the day of Sacha's groundbreaking transplant operation. As he is still overcoming a bereavement, Max wonders whether Sacha is fit to carry out the procedure. Meanwhile, Nicky’s woes escalate when Max finds out that she’s been moonlighting, and Donna has stars in her eyes when she meets a patient who happens to be a casting director.

It’s Valentine’s Day, but will Cupid’s arrow hit the target for Chloe and Cameron? Will Nicky risk a life to pay off a debt? A troubled Sacha is guided by the faith of an old friend.

It’s the morning after the night before, but will Cameron and Chloe reconcile? A familiar face waltzes back into Holby and ruffles a few feathers, and when Jac’s plans with Emma fall through, a colourful character comes to the rescue.

A galvanised Ric clashes with Max as he goes above and beyond for a patient. Essie has to choose between Ben and Sacha, and Kian returns from Canada determined to push Jac out of her comfort zone.

Max finds herself in a desolate place after receiving distressing news, but following her fallout with Ric has she lost her closest confidante? Jac and Kian must decide who will be Darwin’s next clinical lead, but neither is quite ready to make the call. Essie learns that nothing stays secret for long as shocking revelations threaten her friendship with Dom.

Xavier unearths a shocking secret, and Fletch struggles to handle the nursing shortage. Reeling from recent revelations, Sacha, Essie, Dom and Ben peform life-saving surgery on a vulnerable child.

With Xavier hot on his trail, how far will Cameron go to keep Evan dead and buried? Roger Ffolkes forces Ben to own his secrets. Is Ben brave enough to handle the truth? The board scrutinises Jac's team, and she is keen to impress them with a complex and rare surgery that will put the team ahead of the competition. But is everyone ready for a tough day in theatre?

Max is feeling nervous at the thought of seeing her daughter again after years of estrangement. ED nurse David Hide joins the Darwin crew for the day, but Jac deems him not worthy. Essie waits for her routine cancer check-up, while Sacha encourages her to bury the hatchet with Dom.

Max struggles to come to terms with an explosive revelation. Jac and Kian bond over pizza and wine, and Dom tries to reason with a distraught Essie.

As his disciplinary hearing begins, Xav is determined to prove that Cameron killed Evan. Essie faces the fight of her life as she undergoes her first round of chemotherapy.

Essie’s friends try to keep things normal as she continues her chemotherapy. Jac and Kian’s relationship takes an unexpected turn, and can Guy keep his relationship under wraps?

Essie puts on a brave face, but the effects of chemo start to take a toll. Guy has a lot to prove as he faces a challenging case on his first day on AAU, and Jac tries to keep things professional with Kian on the ward, but he has other ideas

As things with Jac heat up, Kian is thrown off balance when a patient causes painful memories to resurface. Tensions run high as Louis adjusts to life in his mum’s hospital, and Guy tries to make amends for last week. Fletch puts his foot in it when he receives an unwanted gift.

Fletch and his daughter Evie reveal life-changing secrets they have both been keeping, and what will Max do when dangerous truths are exposed on the biggest day of her career?

Cameron is gutted when his performance review doesn’t go to plan, and Nicky’s attempts to find a life-saving treatment for Brenda put her at odds with Jac. While staff fuss over Fletch as he recovers from surgery, Essie may know something that will change life on Keller forever.

Nicky is stressed and exhausted, with devastating consequences at work. As she struggles to cope with the pressure from her mother, a tragic incident pushes her over the edge. Ange tells Cameron he is not ready to take the next step in his career. Frustrated by the rejection, he takes out his anger on Louis. Sacha decides to respect Essie's wishes concerning her cancer treatment, but Dominic urges him to persuade her not to give up on palliative care.

Nicky must confront her fears, Fletch and Essie try to remain upbeat, and Guy is determined to prove he's still a top surgeon.

Kian returns to Holby, determined to make amends with Jac. Essie searches for answers, and Ric sets out on a personal vendetta.

Cameron fears new locum Drew is out to expose him, Kian spends the day babysitting Emma in order to win back Jac's heart, and how low will Sacha stoop to convince Essie?

Ric clashes with Max when his determination to destroy Guy puts his health at risk. Distressed by Frankie’s disappearance, Essie’s suspicions are raised when Sacha avoids the subject. Chloe struggles to keep things professional when her dating life spills onto the ward.

Finding Ric unconscious in theatre, Guy capitalises on the unexpected opportunity. Sacha tries to make things right with Essie, and Nicky receives a surprising offer.

Rick wakes up from his coma to find the world is in the middle of a COVID 19 pandemic.

Jac rushes in a mystery patient, whose arrival sets in motion in a deepening medical crisis that could have serious repercussions for her secret relationship with Kian. Keller is shocked when a new member of staff reveals the truth about Sacha's deception, and is tempted to take out his anguish on a vulnerable patient. Cameron basks in the glory of being declared a hero - prompting Nicky to issue him with an ultimatum.

Max wrestles with the after-effects of neurosurgery and the financial pressure on the hospital, but things get worse when an encounter with an old enemy puts a strain on her relationship with Louis. Kian brings in some new recruits to help solve Jac's medical mystery, and a new arrival stirs up unpleasant memories for Donna.

Sacha battles against the odds to keep going after Essie’s death. Cameron tries to win Chloe over, with dramatic consequences. Kian finds himself in a compromised position when Clayton calls him out.

Chloe and Cameron become completely estranged when she finds out that they are competing for the same job. Sacha and Jodie continue to stick together against the naysayers.

Kian’s cold turkey is tested when Sarah Jane calls in a favour. Can Kian stand firm, or will he crack under the pressure?

Sacha buries his head in the sand when Beka is taken ill on New Year’s Eve. Will he figure out the truth before it’s too late?

Kian is on edge as Sarah Jane avoids his calls, and his stash is running out. Can he convince Jac he’s fine when she worries that their relationship is the problem?

It’s total chaos on AAU, and the F1s are daunted when Hanssen leaves them alone to face their first New Year’s night shift. Will they sink or swim?

Skylar’s mistake has fatal consequences, but is she really the one to blame? Kian admits his addiction to Jac, and Donna tries to put Xavier's memory to rest.

It’s the day of the hearing, but who will the panel listen to, Cameron or Skylar? Jac can’t shake her worries about what Kian is getting up to.

A returning patient wreaks havoc for Jac, and Sacha fears for his daughter while Jodie is on the loose.

The hospital is locked down with a gunman on the loose. Trapped in theatre, Cameron needs Nicky's help if he is not to be exposed as being way out of his depth.

Sacha gets the shock of his life when Jodie appears back on the scene. On her first day on Darwin, Jac's replacement, Sahira Shah, doesn't take kindly to Kian. And a bubbly new nurse, Kylie, arrives in acute admissions, but will she survive her first day?

Sacha and Hanssen battle to save Dom’s life in theatre, while Jodie is terrified that she might lose her baby. Sahira tries to steady the good ship Holby, up on Darwin.

Ange blocks Dom's discharge, Alex makes a shocking discovery when a patient arouses his suspicions, and Nicky's health issues return.

Hanssen is shaken when a figure from his past appears. Cameron is backed into a corner when Bobby arrives on the ward threatening to talk. Ange and Dom clash over his decision to sue the hospital.

After learning from Sahira that he may not have been Reyhan's only victim, a distracted Hanssen makes a terrible mistake in theatre. Will it be life-ending for Reyhan?

Cameron holds Ange hostage as the truth of his crimes comes to light. Max needs to look out for Louis, but is she up to it? And Dom is back on the ward for the first time since he decided to sue the hospital.

Reyhan challenges Hanssen to tell Sahira the truth, Nicky vents her frustrations on a shady patient, and the team rally to support Ange after her ordeal with Cameron.