Nick Charles was a private detective who married the wealthy Nora and decided to settle down and leave the good life. Unfortunately for the couple, Nick's past frequently caught up with him and got the couple involved in mystery after mystery. The series was based on the popular MGM series of movies of the 1930's starring William Powell and Myrna Loy. Peter Lawford and Phyllis Kirk starred as the televison versions of Nick and Nora which ran on NBC for two seasons from 1957-59.

Nick (ex detective privato) e Nora Charles, una coppia di coniugi che abitano in un appartamento di Park Avenue a New York, giocano a fare i detective dilettanti, sempre accompagnati dal loro terrier Asta, risolvendo casi riguardanti il crimine.