The God Delusion explores the unproven beliefs that are treated as factual by many religions and the extremes to which some followers have taken them. Dawkins opens the programme by describing the "would-be murderers . . . who want to kill you and me, and themselves, because they're motivated by what they think is the highest ideal." Dawkins argues that "the process of non-thinking called faith" is not a way of understanding the world, but instead stands in fundamental opposition to modern science and the scientific method, and is divisive and dangerous.

In The Virus of Faith, Dawkins opines that the moral framework of religions is warped, and argues against the religious indoctrination of children. The title of this episode comes from The Selfish Gene, in which Dawkins discussed the concept of memes.