Dexter é um especialista forense em amostras de sangue e trabalha para o Departamento de Polícia de Miami. Ele também é um assassino serial que mata as pessoas e que a polícia não consegue prender.

Envolvido com a preparação de seu próximo crime, Dexter descobre que o assassino do caminhão de sorvete conhece sua identidade secreta.

Dexter chega à cena de um crime e descobre que a vítima que havia descartado voltou misteriosamente ao local de seu assassinato. Rita enfrenta seu ex-marido, que insiste em ir à festa de aniversário da filha quando sai da prisão.

O passado de Dexter retorna quando partes de corpos começam a aparecer por toda Miami, presentes do assassino do caminhão de gelo.

The homicide division is handed an unbelievable lead when the Ice Truck Killer's latest victim is found alive but mutilated; Dexter is on the trail of a person who traffics in humans.

The Ice Truck Killer leaves a clue at the scene where Dexter has dispatched his latest victim, and Dexter is worried that someone might have witnessed his killing. Rita is trying to deal with her ex-husband.

The squad identifies the Ice Truck Killer; Rita's ex-husband, an abusive addict, is paroled.

Dexter appears to be connected to a psychiatrist suspected of murdering a suicidal patient.

While on a weekend getaway with Rita, his sister and her new beau, Dexter learns that his biological father, thought to be dead for 30 years, has just passed away, and that he's willed his son everything he owned.

The Ice Truck Killer prepares a crime scene for Dexter: a hotel room all covered in his previous victim's blood. But Dexter does not appreciate this gift, because his childhood memories hunt him.

The Ice Truck Killer sets a trap for Dexter by kidnapping someone close to him; Dexter's increasingly odd behavior piques Doakes's interest.

Dexter figures out who the Ice Truck Killer is, along with a dark secret from his troubled past. Meanwhile, La Guerta is replaced with a new boss and Angel figures out a way how to track the killer while he's still in hospital.