Mladá učiteľka z materskej škôlky dostane priamo na hodine zvláštny záchvat. Dostane sa do nemocnice do starostlivosti tímu Dr. Housea. Lekári hľadajú príčinu jej problémov, záchvaty sa totiž opakujú a stav sa neustále zhoršuje. Prvotné podozrenie na tumor sa nepotvrdí a tím začína byť bezradný. Až vo chvíli, keď Dr. House, uznávaný pre svoje vedomosti, ale v styku s pacientmi tak trochu mrzutý, príde s teóriou, že by žena mohla mať v mozgu parazita, sa objavia prvé úspechy.

Dr. House goes with his gut and performs an unethical act to prove what he suspects to be the link to a teenage lacrosse player's illness in order to save the boy's life.

Dr. House and his team race to save a young man who may have not one, but two illnesses killing him.

A maternity ward epidemic forces House to decide whether to save the life of one child over another.

Dr. House's approach is questioned when he treats a nun for what he believes to be an allergy, not realizing the nun's past is coming back to haunt her.

The case of a schizophrenic mom with a deadly disease and her teenage son who have traded caretaking roles holds a special interest for Dr. House.

Dr. House's diagnosis of a married woman with a rare sleep disorder forces her and her husband to examine their marriage and question their trust for each other.

House and his team have to act fast when a high school student is admitted with a mysterious and lethal poisoning, especially when they discover more teens have been diagnosed with the same deadly illness.

House has to defend himself when he treats a patient who has legally chosen to refuse treatment.

Dr. House and the team treat a homeless woman whose worsening symptoms and unknown identity prove to be a complex mystery.

Dr. House takes Cuddy's challenge to go off his painkillers for a week, but the effects of his withdrawal symptoms may put his patient in danger.

A baseball player's comeback is cut short when he breaks his arm and House and his team have to act fast to figure out what is causing major bone loss that's killing the player and his dreams.

Dr. House's young patient believes his illness is the result of a curse while House uncovers important information about Chase's father.

The hospital's new Chairman of the Board has it out for Dr. House, questioning his importance to the hospital and threatening to eliminate House and his team.

Dr. House and his team race to diagnose a member of the mob and get him well enough to testify and enter the witness protection program while Cuddy works to convince Vogler of House's importance to the hospital.

Dr. House and his team try to uncover the reason a 10-year-old has a heart attack while House suspects one of his team is selling him out to Vogler.

House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.

House and his team battle to diagnose a pregnant patient's life-threatening illness, prompting her to make the most emotional decision of her life, and Vogler is determined to fire House.

House and his team tackle the case of a young man with a penchant for odd behavior, and House prepares for his date with Cameron.

House must decide whether to take the case of his ex-love's husband and he gives medical students a lecture they'll never forget.

House is faced with a problem he may not be able to solve and Stacy returns.