Sherlock is called to London to revisit an old case, where he is forced to face his older brother, Mycroft. Although the siblings suffered a drastic falling-out a few years earlier, Mycroft allows Sherlock and Joan to stay in his new home, 221B Baker Street. With Joan in the middle, the brothers are forced to confront their very complicated history.

When a well-respected mathematician is found dead, Holmes and Watson set out to solve a murder and the purpose of the highly guarded equation he was trying to decipher. Meanwhile, Watson is conflicted when the son of a former patient approaches her for a loan.

When Holmes and Watson set out to track down a civil contractor who leaked classified information, their lives are disrupted when they are targeted by the group of cyber-activists protecting him. Meanwhile, Joan takes the advice of a friend and signs up for an online dating service.

When a financial consulting company CEO is poisoned to death, a woman from Sherlock's past who emerges as a possible suspect.

Holmes and Watson find themselves digging through the dark world of the mob to find a killer when they discover the body of a former assassin. Meanwhile, Watson helps a close friend track down a mystery man who swept her off her feet.

When Captain Gregson’s home is invaded, Holmes and Watson work to find the masked gunman before he strikes again. Meanwhile, Gregson gives his team some insight into his private life.

Sherlock’s brother, Mycroft, arrives in New York and enlists Holmes and Watson to help solve a case involving his former fiancée. Meanwhile, Sherlock has a difficult time accepting Mycroft and Joan’s relationship.

When a beautiful young woman is murdered, Holmes and Watson investigate her ties to a billionaire CEO. Meanwhile, Mycroft makes a case for Sherlock to move back to London.

Holmes and Watson uncover the identity of a serial killer whose case has gone cold and find themselves butting heads with the NYPD.

When an investigation goes horribly wrong, Sherlock must testify in an official police inquiry which jeopardizes his and Watson’s future with the NYPD

When a hedge fund manager who was also running a Ponzi scheme is murdered, Holmes and Watson must determine which of his clients is guilty. Also, Sherlock contemplates sponsoring a fellow recovering addict.

Holmes and Watson come face to face with Moriarty when their one-time adversary is brought in as a consultant on a kidnapping case. Meanwhile, Detective Bell continues his struggle on the road to recovery.

Joan discovers an unsolved murder connected to a rare prehistoric fossil when she reviews one of Sherlock's cold cases; Sherlock's responsibilities as a sobriety sponsor cross personal boundaries.

Holmes’ latest investigation takes him inside a professional dance company when an up-and-coming ballerina is murdered. Meanwhile, Watson embarks on a solo enquiry to find a homeless veteran when his friend alleges he was abducted.

Tensions rise when Holmes and Watson are forced to partner with Gareth Lestrade, Sherlock’s former Scotland Yard colleague, on a bombing investigation.

Holmes and Watson consult on a case in which a man suspected of murdering his wife years ago receives a ransom demand for her safe return. Meanwhile, Lestrade overstays his welcome at the brownstone and seems unwilling to leave.

When a famous cancer researcher is found dead, Holmes and Watson must determine if the scientist’s untimely demise was tied to his latest cutting-edge invention. Meanwhile, Bell is finally cleared to re-enter the field.

A serial killer known for biting his victims appears to be killing again, even though he was presumed dead.

A pickpocket dies of anthrax poisoning, putting Holmes and Watson on the trail of the toxin’s source in order to prevent more deaths.

When Sherlock’s brother Mycroft makes a surprise return to New York, his motivations cause discord between Sherlock and Joan. Meanwhile, a missing person case takes Sherlock and Joan inside the world of unmanned aeronautics.

Business becomes personal for Sherlock when he is forced to partner with his estranged brother, Mycroft, to solve a case with life-or-death consequences.

Holmes and Watson come into contact with MI-6, the British intelligence agency, when a standard murder investigation turns out to have international and political implications. Meanwhile, in the wake of a crisis, Watson reevaluates her relationships with Sherlock and his brother, Mycroft.

Rising tension between Sherlock and Joan brings their partnership to a crossroads, but they endeavor to put their differences aside while they help Sherlock's brother, Mycroft, who faces accusations of treason and murder.