Rodrigo, Ashley, and Shivani of "The Dork Side" go up against Sebastian, Michelle, and Aiden of "Team on a Roll."

Victoria, Tyler, and Melody of "The Brainy Bunch" go up against Ethan, Devananda, and Connor of "The Superlatives." In a "Genius Junior" first, siblings will face off against one another - twins Tyler and Ethan. In the Human GPS round, contestants must memorize the New York City subway routes, before moving on to Number Cruncher, Talking Dictionary, Memory Master, and ultimately "The Cortex."

Christopher, Silvia, and Lance of "99 Problems" take on Norah, Matt, and Paige of "Cheese Cabinet." In the Human GPS round, contestants will memorize all the counties in the United States before moving on to Number Cruncher, Talking Dictionary, Memory Master, and ultimately "The Cortex."

Vinay, Lillian, and Bryan of "The FOGS" go up against "Michi, Jackson, and Ugochi of "Geeks on Fleek." Contestants memorize the intricacies of the San Francisco streets for the Human GPS round. The FOGS nominate Vinay as their "super brain" to handle the Number Cruncher round. Then, the teams take on Talking Dictionary and ultimately, "The Cortex."

Nile, Reagan, and Akshansh of "Legen-Wait For It-dary" take on Treasure, Sebastian, and Apoorva of "The Fast and the Curious." For the Human GPS round, contestants memorize Greyhound bus routes across the United States, before moving onto Number Cruncher, where Akshansh plays as the Super Brain for his team, while Apoorva plays as the Super Brain for her team. The teams then take on Talking Dictionary then ultimately, "The Cortex."

Anna, Vivek, and Summer from "27 Yards" take on Nolan, Eashani, and Jack from "Wicked Smaht." In the Human GPS round, contestants memorize the complex array of galleries included in the Smithsonian collection, before moving on to Number Cruncher and Talking Dictionary. The winning team moves on to "The Cortex."

In the first semi-final, Victoria, Tyler, and Melody of "The Brainy Bunch" will go up against Ashley, Rodrigo, and Shivani of "The Dorkside." Contestants are tested on the complexities of the human nervous system for the Human GPS round, before moving onto Number Cruncher, Talking Dictionary, and Memory Master. Rodrigo serves as the Super Brain for his team, while Tyler is the Super Brain for his team. The winning team moves onto "The Cortex."

In the second semi-final, "Geeks on Fleek" team members Michi, Jackson, and Ugochi take on Christopher, Silvia, and Lance of "99 Problems." For the Human GPS round, contestants are tested on the compartments of a Boeing 737, before moving on to a complex Number Cruncher, Talking Dictionary, and Memory Master. Michi serves as the Super Brain for her team once again, while Christopher serves as the Super Brain for his team.

In the third semi-final, Anna, Vivek, and Summer of "27 Yards" go up against Treasure, Sebastian, and Apoorva of "The Fast and The Curious." Contestants must memorize the various sections of the Titanic for the Human GPS round, before taking on Number Cruncher, Talking Dictionary, and Memory Master. Apoorva is the "Super Brain" for her team on the Number Cruncher while Vivek is the "Super Brain" for Talking Dictionary.